cytochrome c oxidase (Complex IV)

URI: https://gptkb.org/entity/cytochrome_c_oxidase_(Complex_IV)
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:activity oxidoreductase
gptkbp:alternativeName gptkb:Complex_IV
gptkb:cytochrome_aa3
gptkbp:associatedWith gptkb:Leigh_syndrome
gptkb:mitochondrial_complex_IV_deficiency
encephalomyopathy
gptkbp:cofactor gptkb:heme_a3
gptkb:heme_a
copper A
copper B
gptkbp:component electron transport chain
gptkbp:discoveredBy gptkb:David_Keilin
gptkbp:discoveredIn 1920s
gptkbp:EC_number 1.9.3.1
gptkbp:encodedBy mitochondrial DNA (3 subunits)
nuclear DNA (10 subunits)
gptkbp:function catalyzes reduction of oxygen to water
pumps protons across mitochondrial membrane
transfers electrons from cytochrome c to oxygen
gptkbp:gene gptkb:MT-CO2
gptkb:MT-CO3
gptkb:MT-CO1
gptkbp:GO_term gptkb:GO:0004129
https://www.w3.org/2000/01/rdf-schema#label cytochrome c oxidase (Complex IV)
gptkbp:inhibitedBy carbon monoxide
azide
cyanide
gptkbp:locatedIn inner mitochondrial membrane
gptkbp:molecularWeight ~204 kDa (mammalian)
gptkbp:numberOfSubunits 13 (human)
gptkbp:OMIM 220110
gptkbp:PDB 1OCC
gptkbp:presentIn eukaryotes
some bacteria
gptkbp:product gptkb:H2O
oxidized cytochrome c
gptkbp:role cellular respiration
gptkbp:substrate gptkb:O2
gptkb:cytochrome_c
gptkbp:subunit gptkb:COX1
gptkb:COX2
gptkb:COX3
gptkbp:UniProtID P00396 (COX1, human)
P00403 (COX2, human)
P00414 (COX3, human)
gptkbp:bfsParent gptkb:heme_o
gptkbp:bfsLayer 8