cytochrome P450 monooxygenase

URI: https://gptkb.org/entity/cytochrome_P450_monooxygenase
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:absorptionMaximum 450 nm
gptkbp:alsoKnownAs CYP
gptkbp:catalyzes oxidation of organic substances
gptkbp:cofactor gptkb:O2
NADPH
gptkbp:contains hemoglobin
gptkbp:discoveredBy M. J. Klingenberg
gptkbp:discoveredIn 1958
gptkbp:EC_number 1.14.-.-
gptkbp:foundIn gptkb:Bacteria
animals
fungi
plants
gptkbp:function monooxygenation
https://www.w3.org/2000/01/rdf-schema#label cytochrome P450 monooxygenase
gptkbp:importantFor toxicology
pharmacogenomics
biosynthesis of cholesterol
biosynthesis of bile acids
biosynthesis of vitamin D
endogenous metabolism
gptkbp:inducedBy gptkb:rifampicin
gptkb:carbamazepine
phenobarbital
gptkbp:inhibitedBy gptkb:milk
gptkb:macrolide_antibiotics
azole antifungals
gptkbp:involvedIn detoxification
steroid synthesis
drug metabolism
gptkbp:mutationAssociatedWith drug resistance
metabolic disorders
drug sensitivity
gptkbp:numberOfFamiliesInHuman 18
gptkbp:numberOfGenes 57
gptkbp:numberOfSubfamiliesInHuman 44
gptkbp:presentIn gptkb:endoplasmic_reticulum
mitochondria
gptkbp:proteinFamily CYP
gptkbp:structure soluble
membrane-bound
gptkbp:substrate prostaglandins
steroids
fatty acids
xenobiotics
carcinogens
gptkbp:superfamily CYP
gptkbp:bfsParent gptkb:heme-thiolate_monooxygenase
gptkb:EC_1.14.14.23
gptkbp:bfsLayer 7