Statements (70)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
peptidyl-prolyl cis-trans isomerase family
|
| gptkbp:binds |
cyclosporin A
|
| gptkbp:contains |
PPIase domain
|
| gptkbp:discoveredBy |
gptkb:Takeda_Pharmaceutical_Company
|
| gptkbp:example |
gptkb:CYPY
gptkb:CYPT gptkb:CYPN gptkb:CYPL gptkb:CYPR gptkb:CYPA gptkb:Cyclophilin_A gptkb:PPIA gptkb:PPIC gptkb:CYPW gptkb:CYPQ gptkb:CYPE gptkb:CYPC gptkb:PPIF gptkb:CYPH gptkb:CYPX gptkb:CYPS gptkb:CYPK gptkb:CYPZ CYPV CYPM CYPB CYP40 CYP60 CYPD CYPJ CYPP Cyclophilin 40 Cyclophilin B Cyclophilin C Cyclophilin D PPIB PPID PPIE PPIG PPIH PPIL1 PPIL2 PPIL3 PPIL4 PPIL6 PPWD1 |
| gptkbp:firstDescribed |
1984
|
| gptkbp:foundIn |
prokaryotes
eukaryotes |
| gptkbp:function |
catalyzes cis-trans isomerization of proline residues in polypeptides
|
| gptkbp:GeneOntology |
GO:0003755
|
| https://www.w3.org/2000/01/rdf-schema#label |
cyclophilin protein family
|
| gptkbp:InterPro |
IPR002130
|
| gptkbp:involvedIn |
protein folding
immune response |
| gptkbp:memberOf |
immunophilin superfamily
|
| gptkbp:proteinFamily |
PF00160
|
| gptkbp:relatedTo |
FKBP family
parvulin family |
| gptkbp:role |
gptkb:cancer
apoptosis signal transduction neurodegenerative diseases inflammation HIV-1 infection viral replication mitochondrial permeability transition |
| gptkbp:bfsParent |
gptkb:Cyclophilin_A
|
| gptkbp:bfsLayer |
8
|