|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
Cyclophilin F
CypD
|
|
gptkbp:associatedWith
|
gptkb:ischemia-reperfusion_injury
apoptosis
neurodegenerative diseases
cardiovascular diseases
necrosis
|
|
gptkbp:biologicalProcess
|
protein folding
peptidyl-prolyl cis-trans isomerase activity
regulation of cell death
mitochondrial organization
|
|
gptkbp:discoveredBy
|
Fischer et al.
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:Entrez_Gene_ID
|
10105
|
|
gptkbp:enzymeCommissionNumber
|
EC 5.2.1.8
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
|
|
gptkbp:fullName
|
Peptidyl-prolyl cis-trans isomerase F
|
|
gptkbp:function
|
catalyzes cis-trans isomerization of proline imidic peptide bonds in oligopeptides
regulates mitochondrial permeability transition pore (mPTP)
|
|
gptkbp:gene
|
gptkb:PPIF
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOID
|
gptkb:GO:0005739
GO:0003755
|
|
gptkbp:HGNC_ID
|
HGNC:9310
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PPIF
|
|
gptkbp:inhibitedBy
|
cyclosporin A
|
|
gptkbp:interactsWith
|
gptkb:Bcl-2_family_proteins
ANT (adenine nucleotide translocator)
VDAC (voltage-dependent anion channel)
|
|
gptkbp:locatedOnChromosome
|
gptkb:10q22.1
|
|
gptkbp:location
|
mitochondrial matrix
|
|
gptkbp:molecularWeight
|
18 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
Cyclophilin D (mouse)
|
|
gptkbp:PDB
|
2BIT
2Z6W
3U0S
|
|
gptkbp:postTranslationalModification
|
phosphorylation
oxidation
acetylation
|
|
gptkbp:RefSeq
|
NM_005729
NP_005720
|
|
gptkbp:regulates
|
mitochondrial permeability transition
|
|
gptkbp:sequence
|
207 amino acids
|
|
gptkbp:structure
|
contains PPIase domain
|
|
gptkbp:UniProtID
|
P30405
|
|
gptkbp:bfsParent
|
gptkb:Punjab_Population_Innovation_Fund
|
|
gptkbp:bfsLayer
|
7
|