|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
apolipoprotein J
|
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gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
|
|
gptkbp:cleavage
|
secreted form is cleaved into alpha and beta chains
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:CLU_gene
|
|
gptkbp:expressedIn
|
many tissues
|
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gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
lipid transport
apoptosis regulation
chaperone activity
inhibition of complement-mediated cell lysis
|
|
gptkbp:GO
|
gptkb:GO:0006955_(immune_response)
GO:0005615 (extracellular space)
GO:0006869 (lipid transport)
GO:0006915 (apoptotic process)
GO:0005515 (protein binding)
|
|
gptkbp:hasBiomarker
|
gptkb:Alzheimer's_disease
prostate cancer
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
clusterin
|
|
gptkbp:interactsWith
|
gptkb:amyloid-beta
lipoproteins
complement components
|
|
gptkbp:locatedOnChromosome
|
chromosome 8p21-p12
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
extracellular space
|
|
gptkbp:molecularWeight
|
~75-80 kDa
|
|
gptkbp:OMIM
|
185430
|
|
gptkbp:orthologIn
|
gptkb:Bos_taurus
gptkb:Danio_rerio
gptkb:Gallus_gallus
gptkb:Mus_musculus
gptkb:Canis_lupus_familiaris
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
5JYT
|
|
gptkbp:postTranslationalModification
|
glycosylation
|
|
gptkbp:role
|
atherosclerosis
neurodegeneration
immune system regulation
cell death
tumor progression
sperm maturation
tissue remodeling
|
|
gptkbp:structure
|
gptkb:protein
|
|
gptkbp:subunit
|
heterodimer
|
|
gptkbp:UniProtID
|
P10909
|
|
gptkbp:bfsParent
|
gptkb:Sertoli_cells
|
|
gptkbp:bfsLayer
|
6
|