cis-diamminedichloroplatinum(II)

URI: https://gptkb.org/entity/cis-diamminedichloroplatinum(II)
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
antineoplastic agent
coordination complex
platinum complex
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode L01XA01
gptkbp:CASNumber 15663-27-1
gptkbp:chemicalFormula Cl2H6N2Pt
gptkbp:commonName gptkb:cisplatin
gptkbp:containsElement gptkb:chlorine
hydrogen
nitrogen
platinum
gptkbp:coordinationNumber 4
gptkbp:discoveredBy gptkb:Michele_Peyrone
gptkbp:discoveredIn 1845
https://www.w3.org/2000/01/rdf-schema#label cis-diamminedichloroplatinum(II)
gptkbp:isomerOf trans-diamminedichloroplatinum(II)
gptkbp:IUPACName gptkb:cis-diamminedichloroplatinum(II)
gptkbp:legalStatus prescription only
gptkbp:ligand ammonia
chloride
gptkbp:mechanismOfAction DNA crosslinking
inhibits DNA synthesis
gptkbp:meltingPoint 270°C (decomposes)
gptkbp:molecularWeight 300.05 g/mol
gptkbp:oxidationStateOfPlatinum +2
gptkbp:PubChem_CID 441203
CHEMBL11359
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect nausea
vomiting
nephrotoxicity
neurotoxicity
ototoxicity
myelosuppression
gptkbp:solubility slightly soluble
gptkbp:structure square planar
gptkbp:UNII Q20Q21Q62J
gptkbp:usedFor gptkb:cancer
esophageal cancer
testicular cancer
chemotherapy
bladder cancer
head and neck cancer
gastric cancer
gptkbp:bfsParent gptkb:Cisplatina
gptkb:Cisplatin
gptkb:cisplatin
gptkbp:bfsLayer 7