|
gptkbp:instanceOf
|
Chemotherapy drug
Platinum-based antineoplastic agent
|
|
gptkbp:administeredBy
|
Intravenous injection
|
|
gptkbp:approvalYear
|
1978
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:aroma
|
Odorless
|
|
gptkbp:ATCCode
|
L01XA01
|
|
gptkbp:CASNumber
|
15663-27-1
|
|
gptkbp:chemicalFormula
|
Cl2H6N2Pt
|
|
gptkbp:color
|
Yellow
|
|
gptkbp:discoveredBy
|
gptkb:Michele_Peyrone
|
|
gptkbp:discoveredIn
|
1845
|
|
gptkbp:eliminatedIn
|
Renal
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cisplatina
|
|
gptkbp:includesState
|
gptkb:stone
|
|
gptkbp:IUPACName
|
gptkb:cis-diamminedichloroplatinum(II)
|
|
gptkbp:KEGGID
|
D00275
|
|
gptkbp:legalStatus
|
Prescription only
|
|
gptkbp:listedOn
|
gptkb:WHO_Model_List_of_Essential_Medicines
|
|
gptkbp:mechanismOfAction
|
DNA crosslinking
Inhibition of DNA synthesis
|
|
gptkbp:meltingPoint
|
270°C (decomposes)
|
|
gptkbp:molecularWeight
|
300.05 g/mol
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1351
441203
DB00515
390910
|
|
gptkbp:relatedTo
|
gptkb:Oxaliplatin
gptkb:Carboplatin
|
|
gptkbp:sideEffect
|
gptkb:Nausea
Vomiting
Myelosuppression
Nephrotoxicity
Ototoxicity
Peripheral neuropathy
|
|
gptkbp:solubility
|
Slightly soluble in water
|
|
gptkbp:synonym
|
gptkb:cisplatin
gptkb:cis-diamminedichloroplatinum(II)
|
|
gptkbp:UNII
|
Q20Q21Q62J
|
|
gptkbp:usedFor
|
gptkb:Head_and_neck_cancer
gptkb:Bladder_cancer
Cancer treatment
Lung cancer
Ovarian cancer
Testicular cancer
|
|
gptkbp:bfsParent
|
gptkb:Brazilian_War_of_Independence
|
|
gptkbp:bfsLayer
|
6
|