skeletal ryanodine receptor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein ion channel
gptkbp:alternativeName	gptkb:RYR1 gptkb:ryanodine_receptor_1 gptkb:skeletal_muscle_ryanodine_receptor
gptkbp:associatedWith	gptkb:central_core_disease malignant hyperthermia
gptkbp:biologicalProcess	calcium channel activity
gptkbp:discoveredBy	gptkb:Andrew_Marks
gptkbp:encodedBy	gptkb:RYR1_gene
gptkbp:foundIn	gptkb:skeletal_muscle
gptkbp:function	calcium release from sarcoplasmic reticulum
https://www.w3.org/2000/01/rdf-schema#label	skeletal ryanodine receptor
gptkbp:ligand	gptkb:ATP gptkb:dantrolene calcium caffeine ryanodine
gptkbp:locatedOnChromosome	19q13.1
gptkbp:mass	~2.2 MDa
gptkbp:mutationAssociatedWith	muscle weakness susceptibility to anesthesia-induced complications
gptkbp:OMIM	180901
gptkbp:regulates	modulated by FKBP12 modulated by calmodulin modulated by phosphorylation
gptkbp:species	gptkb:Mus_musculus gptkb:Homo_sapiens gptkb:Rattus_norvegicus
gptkbp:structure	homotetramer
gptkbp:subcellularLocation	sarcoplasmic reticulum membrane
gptkbp:UniProtID	P21817
gptkbp:bfsParent	gptkb:cardiac_ryanodine_receptor
gptkbp:bfsLayer	8