skeletal muscle ryanodine receptor (RyR1)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein ion channel
gptkbp:alternativeName	gptkb:RYR1 gptkb:RYR gptkb:ryanodine_receptor_1 MHS skeletal muscle-type ryanodine receptor
gptkbp:associatedWith	gptkb:central_core_disease gptkb:multiminicore_disease gptkb:RyR2 malignant hyperthermia RyR3
gptkbp:biologicalProcess	calcium channel activity ryanodine binding
gptkbp:discoveredBy	gptkb:Andrew_Marks
gptkbp:encodedBy	gptkb:RYR1_gene
gptkbp:firstDescribed	1989
gptkbp:foundIn	gptkb:skeletal_muscle
gptkbp:function	mediates release of calcium from sarcoplasmic reticulum
gptkbp:gene	gptkb:RYR1
https://www.w3.org/2000/01/rdf-schema#label	skeletal muscle ryanodine receptor (RyR1)
gptkbp:interactsWith	dihydropyridine receptor (DHPR)
gptkbp:length	5038
gptkbp:locatedOnChromosome	19q13.2
gptkbp:modulatedBy	gptkb:ATP gptkb:calmodulin gptkb:dantrolene magnesium caffeine ryanodine
gptkbp:mutationAssociatedWith	gptkb:central_core_disease gptkb:multiminicore_disease muscular dystrophy malignant hyperthermia susceptibility
gptkbp:orthologInMouse	gptkb:Ryr1
gptkbp:PDB	gptkb:5TAL gptkb:5T15 6MZP 6MZQ 6MZR 6MZS 6MZT 6MZU 6MZV 6MZW 6MZX 6MZY 6MZZ
gptkbp:structure	homotetramer
gptkbp:subcellularLocation	sarcoplasmic reticulum membrane
gptkbp:UniProtID	P21817
gptkbp:bfsParent	gptkb:cardiac_muscle_ryanodine_receptor
gptkbp:bfsLayer	8