aspartate aminotransferase

URI: https://gptkb.org/entity/aspartate_aminotransferase
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:abbreviation gptkb:SGOT
AST
gptkbp:alternativeName gptkb:glutamate_oxaloacetate_transaminase
gptkbp:CASNumber 9000-97-9
gptkbp:catalyzes transamination of aspartate and α-ketoglutarate
gptkbp:cofactor gptkb:pyridoxal_phosphate
gptkbp:EC_number 2.6.1.1
gptkbp:enzymeClassification transferase
gptkbp:firstDescribed 1955
gptkbp:foundIn gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
gptkbp:gene gptkb:GOT1
gptkb:GOT2
gptkbp:half-life_in_serum ~17 hours
https://www.w3.org/2000/01/rdf-schema#label aspartate aminotransferase
gptkbp:inhibitedBy gptkb:aminooxyacetic_acid
gptkbp:marking hepatocellular injury
muscle injury
gptkbp:measures blood plasma
serum
gptkbp:molecularWeight ~45 kDa (monomer)
gptkbp:organism gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Bacteria
gptkbp:pathway gptkb:urea_cycle
amino acid metabolism
gluconeogenesis
gptkbp:PDB gptkb:1AJS
7AAT
gptkbp:product gptkb:oxaloacetate
glutamate
gptkbp:significance elevated in myocardial infarction
elevated in liver damage
gptkbp:structure homodimer
gptkbp:subcellularLocation gptkb:cytoplasm
mitochondria
gptkbp:substrate gptkb:α-ketoglutarate
gptkb:aspartate
gptkbp:UniProtID gptkb:P00505_(mitochondrial)
P17174 (cytoplasmic)
gptkbp:used_in liver function test
gptkbp:bfsParent gptkb:oxaloacetate
gptkbp:bfsLayer 6