|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:activeIngredient
|
gptkb:alteplase
|
|
gptkbp:approvalYear
|
1987
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
B01AD02
|
|
gptkbp:CASNumber
|
105857-23-6
|
|
gptkbp:contraindication
|
history of intracranial hemorrhage
active internal bleeding
|
|
gptkbp:drugClass
|
gptkb:tissue_plasminogen_activator
|
|
gptkbp:form
|
lyophilized powder for injection
|
|
gptkbp:genericName
|
gptkb:alteplase
|
|
gptkbp:halfLife
|
about 5 minutes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Activase
|
|
gptkbp:indication
|
gptkb:acute_myocardial_infarction
pulmonary embolism
acute ischemic stroke
|
|
gptkbp:isBiosimilarAvailable
|
no
|
|
gptkbp:KEGGID
|
D02842
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:manufacturer
|
gptkb:Genentech
|
|
gptkbp:mechanismOfAction
|
gptkb:tissue_plasminogen_activator
|
|
gptkbp:MedlinePlusID
|
a601112
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:product
|
gptkb:protein
|
|
gptkbp:routeOfAdministration
|
intravenous
|
|
gptkbp:RxNormID
|
197795
|
|
gptkbp:sideEffect
|
bleeding
allergic reaction
hypotension
|
|
gptkbp:storage
|
refrigerate at 2-8°C
|
|
gptkbp:UNII
|
QGJ20R5F9H
|
|
gptkbp:bfsParent
|
gptkb:Genentech
|
|
gptkbp:bfsLayer
|
5
|