|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredBy
|
gptkb:F._O._Schmitt
|
|
gptkbp:discoveredIn
|
1964
|
|
gptkbp:domain
|
gptkb:EF-hand_domain
actin-binding domain
spectrin-like repeats
|
|
gptkbp:foundIn
|
muscle cells
non-muscle cells
|
|
gptkbp:function
|
gptkb:actin-binding_protein
crosslinks actin filaments
|
|
gptkbp:gene
|
gptkb:ACTN1
gptkb:ACTN2
gptkb:ACTN3
gptkb:ACTN4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
alpha-actinin
|
|
gptkbp:interactsWith
|
gptkb:actin
gptkb:integrins
gptkb:vinculin
gptkb:titin
|
|
gptkbp:location
|
cytoskeleton
Z-disc of sarcomere
|
|
gptkbp:molecularWeight
|
~100 kDa
|
|
gptkbp:mutationAssociatedWith
|
muscular dystrophy
focal segmental glomerulosclerosis
|
|
gptkbp:OMIM
|
gptkb:102573_(ACTN2)
gptkb:102574_(ACTN3)
gptkb:102575_(ACTN1)
gptkb:604638_(ACTN4)
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:yeast
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
gptkb:1SJJ
|
|
gptkbp:proteinFamily
|
gptkb:ACTN
|
|
gptkbp:regulates
|
phosphorylation
calcium binding
|
|
gptkbp:role
|
muscle contraction
cell adhesion
cell motility
cytoskeletal organization
|
|
gptkbp:structure
|
homodimer
rod-shaped
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:cytoplasm
focal adhesions
|
|
gptkbp:UniProtID
|
gptkb:O43707_(ACTN4)
gptkb:P12814_(ACTN1)
P35609 (ACTN2)
Q08043 (ACTN3)
|
|
gptkbp:bfsParent
|
gptkb:Z_line
gptkb:myopalladin
|
|
gptkbp:bfsLayer
|
7
|