Statements (104)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alsoKnownAs |
gptkb:SIP1
zinc finger E-box-binding homeobox 2 |
| gptkbp:associatedWith |
gptkb:Mowat-Wilson_syndrome
|
| gptkbp:binds |
E-box sequences
|
| gptkbp:discoveredBy |
Verschueren et al.
|
| gptkbp:discoveredIn |
1999
|
| gptkbp:encodes |
ZEB2 protein
|
| gptkbp:Entrez_Gene_ID |
9839
ENSG00000169554 |
| gptkbp:expressedIn |
gptkb:nervous_system
various tissues |
| gptkbp:function |
transcription factor
regulation of epithelial-mesenchymal transition |
| gptkbp:geneType |
protein-coding
|
| gptkbp:hasHomeodomain |
yes
|
| gptkbp:hasTranscriptVariant |
multiple
|
| gptkbp:hasZincFingerDomain |
yes
|
| gptkbp:HGNC_ID |
HGNC:29081
|
| https://www.w3.org/2000/01/rdf-schema#label |
ZEB2
|
| gptkbp:interactsWith |
gptkb:SMAD_proteins
CtBP1 CtBP2 |
| gptkbp:locatedOnChromosome |
2q22.3
|
| gptkbp:mutationAssociatedWith |
intellectual disability
congenital malformations |
| gptkbp:OMIM |
605802
|
| gptkbp:orthologInMouse |
Zeb2
|
| gptkbp:regulates |
gptkb:TGF-beta_signaling_pathway
apoptosis cell differentiation cell proliferation wound healing DNA repair cellular senescence lactation pluripotency angiogenesis cell migration eye development metastasis cell cycle cell fate determination stem cell maintenance craniofacial development kidney development neural development myelination autophagy fibrosis erythropoiesis B cell differentiation hematopoiesis lymphopoiesis adipogenesis adrenal development bone development cardiac development gonadal development lung development spermatogenesis vascular development immune system development chondrogenesis tumor progression hair follicle development osteogenesis placental development lymphangiogenesis skeletal muscle development oogenesis macrophage polarization tooth development oligodendrocyte differentiation prostate development testis development mammary gland development folliculogenesis pancreatic development T cell differentiation neural crest cell migration pituitary development intestinal development liver development skin development urogenital development immune cell differentiation uterine development megakaryopoiesis astrocyte differentiation dendritic cell development granulopoiesis inner ear development monocytopoiesis natural killer cell development ovary development placental trophoblast differentiation thymic development |
| gptkbp:represses |
gptkb:E-cadherin
|
| gptkbp:UniProtID |
O60315
|
| gptkbp:bfsParent |
gptkb:miR-192
gptkb:AP-2 gptkb:MiR200 |
| gptkbp:bfsLayer |
7
|