Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alias |
YAP65
Yes-associated protein 1 |
| gptkbp:alternativeSplicing |
produces multiple isoforms
|
| gptkbp:associatedWith |
gptkb:cancer
colorectal cancer hepatocellular carcinoma |
| gptkbp:biologicalProcess |
stem cell maintenance
tissue regeneration epithelial-mesenchymal transition |
| gptkbp:discoveredBy |
Sudol M et al.
|
| gptkbp:discoveredIn |
1995
|
| gptkbp:encodedBy |
YAP1 gene
|
| gptkbp:fullName |
Yes-associated protein
|
| gptkbp:function |
regulation of apoptosis
regulation of cell proliferation transcriptional co-activator |
| gptkbp:gene |
gptkb:YAP1
|
| gptkbp:GO |
GO:0005634 (nucleus)
GO:0001228 (transcriptional activator activity) |
| https://www.w3.org/2000/01/rdf-schema#label |
YAP protein
|
| gptkbp:inhibitedBy |
verteporfin
|
| gptkbp:interactsWith |
TEAD transcription factors
|
| gptkbp:locale |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:locatedOnChromosome |
11q22
|
| gptkbp:molecularWeight |
~65 kDa
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
Drosophila Yorkie
mouse YAP |
| gptkbp:pathway |
gptkb:Hippo_signaling_pathway
|
| gptkbp:PDB |
3KYS
|
| gptkbp:phosphorylates |
LATS1/2 kinases
Serine 127 retained in cytoplasm |
| gptkbp:postTranslationalModification |
phosphorylation
sumoylation ubiquitination |
| gptkbp:regulates |
activated when Hippo pathway is off
inhibited by Hippo pathway |
| gptkbp:role |
organ size control
|
| gptkbp:roleInCancer |
tumor suppressor
|
| gptkbp:structure |
contains PDZ-binding motif
contains WW domains |
| gptkbp:UniProtID |
P46937
|
| gptkbp:unphosphorylatedForm |
translocates to nucleus
|
| gptkbp:bfsParent |
gptkb:WW_domain
|
| gptkbp:bfsLayer |
7
|