|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
premature aging
genomic instability syndromes
|
|
gptkbp:domain
|
nuclear localization signal
RecQ helicase domain
exonuclease domain
|
|
gptkbp:encodedBy
|
gptkb:WRN_gene
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
DNA helicase activity
exonuclease activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
WRN protein
|
|
gptkbp:interactsWith
|
gptkb:p53_protein
gptkb:DNA_polymerase_delta
RPA protein
FEN1 protein
Ku70/Ku80 complex
|
|
gptkbp:involvedIn
|
DNA repair
genomic stability
|
|
gptkbp:locatedOnChromosome
|
gptkb:8p12
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
162 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Werner_syndrome
|
|
gptkbp:OMIM
|
604611
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Pan_troglodytes
|
|
gptkbp:PDB
|
gptkb:2WWY
3AAF
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:requires
|
telomere maintenance
replication fork stability
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:OMIM
gptkb:UniProt
|
|
gptkbp:structure
|
multi-domain
|
|
gptkbp:UniProtID
|
gptkb:Q14191
|
|
gptkbp:bfsParent
|
gptkb:RecQ_helicase_family
|
|
gptkbp:bfsLayer
|
7
|