Vesicular monoamine transporter
GPTKB entity
Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:VMAT
|
| gptkbp:associatedWith |
monoaminergic neurons
|
| gptkbp:foundIn |
neurons
neuroendocrine cells |
| gptkbp:function |
transports monoamines into synaptic vesicles
|
| gptkbp:gene |
gptkb:SLC18A1
gptkb:SLC18A2 |
| gptkbp:hasIsoform |
gptkb:VMAT1
gptkb:VMAT2 |
| https://www.w3.org/2000/01/rdf-schema#label |
Vesicular monoamine transporter
|
| gptkbp:inhibitedBy |
gptkb:tetrabenazine
gptkb:reserpine |
| gptkbp:location |
synaptic vesicle membrane
|
| gptkbp:memberOf |
gptkb:solute_carrier_family
|
| gptkbp:role |
regulates neurotransmitter release
regulates neurotransmitter storage |
| gptkbp:significance |
target for antidepressant drugs
implicated in Parkinson's disease implicated in depression target for antipsychotic drugs |
| gptkbp:transportation |
gptkb:histamine
dopamine norepinephrine serotonin epinephrine |
| gptkbp:type |
integral membrane protein
|
| gptkbp:bfsParent |
gptkb:VMAT
|
| gptkbp:bfsLayer |
7
|