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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alsoKnownAs
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Phosphatidylinositol 3-kinase catalytic subunit type 3
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gptkbp:complexComponentOf
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Class III PI3K complex
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gptkbp:discoveredIn
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gptkb:Saccharomyces_cerevisiae
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gptkbp:enzymeClassification
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gptkb:EC_2.7.1.137
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gptkbp:function
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autophagy regulation
endocytic trafficking
phosphatidylinositol 3-kinase activity
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gptkbp:gene
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gptkb:PIK3C3
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https://www.w3.org/2000/01/rdf-schema#label
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VPS34 protein
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gptkbp:inhibitedBy
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gptkb:3-methyladenine
gptkb:Wortmannin
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gptkbp:interactsWith
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gptkb:Beclin-1
gptkb:ATG14L
gptkb:UVRAG
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gptkbp:involvedIn
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autophagosome formation
endosomal sorting
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gptkbp:location
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gptkb:lysosome
gptkb:endosome
gptkb:cytoplasm
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gptkbp:molecularWeight
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~100 kDa
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gptkbp:mutationAssociatedWith
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gptkb:cancer
neurodegenerative diseases
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:orthologIn
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yeast Vps34p
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gptkbp:phosphorylates
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phosphatidylinositol
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gptkbp:product
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phosphatidylinositol 3-phosphate
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gptkbp:requires
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cell survival
membrane trafficking
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gptkbp:structure
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contains C2 domain
contains PI3K catalytic domain
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gptkbp:bfsParent
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gptkb:PIK3C3
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gptkbp:bfsLayer
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6
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