Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alias |
gptkb:VLDL_receptor
gptkb:VLDLR gptkb:VLDL-R |
| gptkbp:alternativeSplicing |
produces multiple isoforms
|
| gptkbp:associatedWith |
cerebellar hypoplasia and mental retardation
Reelin signaling pathway disorders |
| gptkbp:component |
integral component of plasma membrane
|
| gptkbp:encodedBy |
gptkb:VLDLR_gene
|
| gptkbp:Entrez_Gene_ID |
7436
|
| gptkbp:family |
gptkb:low-density_lipoprotein_receptor_family
|
| gptkbp:fullName |
Very Low-Density Lipoprotein Receptor
|
| gptkbp:function |
lipoprotein particle receptor activity
mediates endocytosis of VLDL receptor for very low-density lipoprotein (VLDL) |
| gptkbp:GOProcess |
cholesterol homeostasis
|
| https://www.w3.org/2000/01/rdf-schema#label |
VLDLR protein
|
| gptkbp:interactsWith |
gptkb:ApoE
gptkb:Reelin Dab1 |
| gptkbp:ligand |
apolipoprotein E (ApoE)
very low-density lipoprotein (VLDL) |
| gptkbp:locatedOnChromosome |
chromosome 9p24
|
| gptkbp:location |
gptkb:cell_membrane
gptkb:plasma_membrane |
| gptkbp:molecularWeight |
~97 kDa
|
| gptkbp:OMIM |
192977
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
mouse Vldlr protein
rat Vldlr protein |
| gptkbp:pathway |
gptkb:Reelin_signaling_pathway
lipid metabolism |
| gptkbp:PDB |
2WBO
|
| gptkbp:postTranslationalModification |
phosphorylation
glycosylation |
| gptkbp:significance |
mutations cause VLDLR-associated cerebellar hypoplasia
|
| gptkbp:structure |
contains EGF-like domains
contains transmembrane domain contains O-linked sugar domain contains cytoplasmic tail contains ligand-binding repeats |
| gptkbp:tissue_specificity |
gptkb:skeletal_muscle
gptkb:kidney gptkb:placenta brain heart adipose tissue |
| gptkbp:UniProtID |
P98155
|
| gptkbp:bfsParent |
gptkb:VLDLR
|
| gptkbp:bfsLayer |
7
|