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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alias
|
gptkb:VLDL_receptor
gptkb:VLDLR
gptkb:VLDL-R
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
cerebellar hypoplasia and mental retardation
Reelin signaling pathway disorders
|
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gptkbp:component
|
integral component of plasma membrane
|
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gptkbp:encodedBy
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gptkb:VLDLR_gene
|
|
gptkbp:Entrez_Gene_ID
|
7436
|
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gptkbp:family
|
gptkb:low-density_lipoprotein_receptor_family
|
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gptkbp:fullName
|
Very Low-Density Lipoprotein Receptor
|
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gptkbp:function
|
lipoprotein particle receptor activity
mediates endocytosis of VLDL
receptor for very low-density lipoprotein (VLDL)
|
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gptkbp:GOProcess
|
cholesterol homeostasis
|
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gptkbp:interactsWith
|
gptkb:ApoE
gptkb:Reelin
Dab1
|
|
gptkbp:ligand
|
apolipoprotein E (ApoE)
very low-density lipoprotein (VLDL)
|
|
gptkbp:locatedOnChromosome
|
chromosome 9p24
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
~97 kDa
|
|
gptkbp:OMIM
|
192977
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Vldlr protein
rat Vldlr protein
|
|
gptkbp:pathway
|
gptkb:Reelin_signaling_pathway
lipid metabolism
|
|
gptkbp:PDB
|
2WBO
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:significance
|
mutations cause VLDLR-associated cerebellar hypoplasia
|
|
gptkbp:structure
|
contains EGF-like domains
contains transmembrane domain
contains O-linked sugar domain
contains cytoplasmic tail
contains ligand-binding repeats
|
|
gptkbp:tissue_specificity
|
gptkb:adipose_tissue
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
brain
heart
|
|
gptkbp:UniProtID
|
P98155
|
|
gptkbp:bfsParent
|
gptkb:VLDLR
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VLDLR protein
|