VAV proto-oncogene, guanine nucleotide exchange factor 1
GPTKB entity
Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:associatedWith |
leukemia
oncogenesis |
| gptkbp:discoveredIn |
1992
|
| gptkbp:encodes |
Vav1 protein
|
| gptkbp:Entrez_Gene_ID |
7409
|
| gptkbp:expressedIn |
hematopoietic cells
|
| gptkbp:function |
guanine nucleotide exchange factor
signal transduction |
| gptkbp:geneType |
protein coding
|
| gptkbp:HGNC_ID |
12658
|
| https://www.w3.org/2000/01/rdf-schema#label |
VAV proto-oncogene, guanine nucleotide exchange factor 1
|
| gptkbp:interactsWith |
gptkb:LCK
gptkb:SHP-2 gptkb:ZAP-70 gptkb:GRB2 |
| gptkbp:involvedIn |
T cell development
hematopoiesis |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_19
|
| gptkbp:OMIM |
193163
|
| gptkbp:orthologInMouse |
gptkb:Vav1
|
| gptkbp:phosphorylates |
tyrosine kinases
|
| gptkbp:regulates |
Rho/Rac GTPases
|
| gptkbp:subcellularLocation |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:symbol |
gptkb:VAV1
|
| gptkbp:UniProtID |
P15498
|
| gptkbp:bfsParent |
gptkb:Vav1
|
| gptkbp:bfsLayer |
7
|