|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
TACSTD2
tumor-associated calcium signal transducer 2
|
|
gptkbp:antibodyTarget
|
monoclonal antibodies
|
|
gptkbp:associatedWith
|
various carcinomas
|
|
gptkbp:discoveredBy
|
S. F. Linnoila et al.
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:domain
|
EGF-like domain
thyroglobulin type-1 domain
|
|
gptkbp:Entrez_Gene_ID
|
4070
ENSG00000119922
|
|
gptkbp:expressedIn
|
epithelial cells
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
cell proliferation
signal transduction
cell surface receptor
|
|
gptkbp:gene
|
TACSTD2
|
|
gptkbp:glycosylation
|
N-linked
|
|
gptkbp:HGNC_ID
|
11531
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Trop-2
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p32
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
~40 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:congenital_tufting_enteropathy
gelatinous drop-like corneal dystrophy
|
|
gptkbp:OMIM
|
185530
|
|
gptkbp:orthologIn
|
gptkb:dog
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:overexpressedIn
|
gptkb:cancer
colorectal cancer
pancreatic cancer
prostate cancer
head and neck cancer
gastric cancer
|
|
gptkbp:relatedTo
|
metastasis
cell adhesion
tumor progression
|
|
gptkbp:structure
|
single-pass type I membrane protein
|
|
gptkbp:target
|
gptkb:sacituzumab_govitecan
antibody-drug conjugates
|
|
gptkbp:targetOfDrug
|
gptkb:non-small_cell_lung_cancer
gptkb:triple-negative_breast_cancer
metastatic urothelial cancer
|
|
gptkbp:UniProtID
|
P09758
|
|
gptkbp:bfsParent
|
gptkb:Trodelvy
|
|
gptkbp:bfsLayer
|
7
|