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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeSplicing
|
TrkC truncated isoforms
|
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gptkbp:domain
|
extracellular domain
transmembrane domain
intracellular tyrosine kinase domain
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gptkbp:downstreamOf
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gptkb:PLCĪ³_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
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gptkbp:encodedBy
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gptkb:NTRK3_gene
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gptkbp:expressedIn
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gptkb:nervous_system
brain
peripheral nervous system
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gptkbp:function
|
receptor tyrosine kinase activity
mediates neurotrophin signaling
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gptkbp:hasIsoform
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gptkb:TrkC
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gptkbp:ligand
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gptkb:neurotrophin-3_(NT-3)
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gptkbp:locale
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gptkb:plasma_membrane
|
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gptkbp:molecularWeight
|
~145 kDa
|
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gptkbp:mutationAssociatedWith
|
gptkb:cancer
congenital insensitivity to pain with anhidrosis (CIPA)
|
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gptkbp:orthologIn
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gptkb:mouse
gptkb:right
gptkb:zebrafish
|
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gptkbp:phosphorylates
|
autophosphorylation upon ligand binding
|
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gptkbp:role
|
neurite outgrowth
neuronal differentiation
neuronal survival
|
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gptkbp:bfsParent
|
gptkb:TrkC
|
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gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TrkC full-length
|