Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeSplicing |
TrkC truncated isoforms
|
| gptkbp:domain |
extracellular domain
transmembrane domain intracellular tyrosine kinase domain |
| gptkbp:downstreamOf |
gptkb:PLCĪ³_pathway
gptkb:MAPK/ERK_pathway gptkb:PI3K/AKT_pathway |
| gptkbp:encodedBy |
gptkb:NTRK3_gene
|
| gptkbp:expressedIn |
gptkb:nervous_system
brain peripheral nervous system |
| gptkbp:function |
receptor tyrosine kinase activity
mediates neurotrophin signaling |
| gptkbp:hasIsoform |
gptkb:TrkC
|
| https://www.w3.org/2000/01/rdf-schema#label |
TrkC full-length
|
| gptkbp:ligand |
gptkb:neurotrophin-3_(NT-3)
|
| gptkbp:locale |
gptkb:plasma_membrane
|
| gptkbp:molecularWeight |
~145 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
congenital insensitivity to pain with anhidrosis (CIPA) |
| gptkbp:orthologIn |
gptkb:mouse
gptkb:zebrafish right |
| gptkbp:phosphorylates |
autophosphorylation upon ligand binding
|
| gptkbp:role |
neurite outgrowth
neuronal differentiation neuronal survival |
| gptkbp:bfsParent |
gptkb:TrkC
|
| gptkbp:bfsLayer |
7
|