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gptkbp:instanceOf
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gptkb:gene
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gptkbp:alternativeName
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gptkb:GP145-TrkC
gptkb:TRKC
neurotrophic tyrosine kinase receptor type 3
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gptkbp:alternativeSplicing
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produces multiple isoforms
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gptkbp:associatedWith
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gptkb:neuroblastoma
gptkb:cancer
congenital heart defects
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gptkbp:discoveredBy
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1991
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gptkbp:encodes
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gptkb:TrkC_protein
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gptkbp:Entrez_Gene_ID
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4915
ENSG00000140538
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gptkbp:expressedIn
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gptkb:skeletal_muscle
gptkb:nervous_system
heart
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gptkbp:fullName
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gptkb:neurotrophic_receptor_tyrosine_kinase_3
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gptkbp:function
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encodes a receptor tyrosine kinase involved in neurotrophin signaling
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gptkbp:gene_fusion_partner
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gptkb:ETV6
gptkb:EML4
gptkb:TPM3
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gptkbp:geneType
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protein-coding
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gptkbp:HGNC_ID
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gptkb:NTRK3
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https://www.w3.org/2000/01/rdf-schema#label
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NTRK3 gene
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gptkbp:ligand
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gptkb:neurotrophin-3_(NT-3)
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gptkbp:locatedOnChromosome
|
15
15q25
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gptkbp:mutationAssociatedWith
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gptkb:gene
can lead to developmental disorders
can be oncogenic
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gptkbp:OMIM
|
191316
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gptkbp:orthologInMouse
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gptkb:Ntrk3
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gptkbp:pathway
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gptkb:neurotrophin_signaling_pathway
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gptkbp:product
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gptkb:TrkC
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gptkbp:proteinFamily
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immunoglobulin-like domain
leucine-rich repeat domain
tyrosine kinase domain
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gptkbp:RefSeq
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NM_002530
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gptkbp:regulates
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gptkb:synaptic_plasticity
neuronal differentiation
neuronal survival
axon guidance
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gptkbp:significance
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target for cancer therapy
biomarker for certain tumors
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gptkbp:subcellularLocation
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gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
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gptkbp:target
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gptkb:TRK_inhibitors
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gptkbp:UniProtID
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Q16288
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gptkbp:bfsParent
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gptkb:TrkC
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gptkbp:bfsLayer
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7
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