telomere terminal transferase
GPTKB entity
Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activity |
reverse transcriptase
|
| gptkbp:alsoKnownAs |
telomerase
|
| gptkbp:associatedWith |
stem cells
immortalized cells |
| gptkbp:component |
RNA component (TERC)
protein component (TERT) |
| gptkbp:discoveredBy |
gptkb:Carol_Greider
gptkb:Elizabeth_Blackburn |
| gptkbp:discoveredIn |
1985
|
| gptkbp:EC_number |
2.7.7.49
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
adds telomeric repeat sequences to the ends of chromosomes
|
| gptkbp:gene |
gptkb:TERC
gptkb:TERT |
| gptkbp:GO_term |
GO:0003720
|
| https://www.w3.org/2000/01/rdf-schema#label |
telomere terminal transferase
|
| gptkbp:inhibitedBy |
gptkb:BIBR1532
|
| gptkbp:locatedIn |
gptkb:nucleus
|
| gptkbp:relatedTo |
gptkb:cancer
cellular aging |
| gptkbp:role |
maintains chromosome ends
|
| gptkbp:substrate |
deoxynucleoside triphosphates
telomeric DNA |
| gptkbp:UniProtID |
O14746 (human TERT)
|
| gptkbp:bfsParent |
gptkb:Telomerase
|
| gptkbp:bfsLayer |
7
|