|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:OPG
osteoprotegerin
OCIF
osteoclastogenesis inhibitory factor
|
|
gptkbp:associatedWith
|
gptkb:bone
gptkb:Paget's_disease_of_bone
vascular calcification
|
|
gptkbp:disulfideBond
|
present
|
|
gptkbp:encodes
|
osteoprotegerin
|
|
gptkbp:Entrez_Gene_ID
|
4982
ENSG00000119866
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:bone
gptkb:kidney
heart
liver
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
acts as a decoy receptor for RANKL
inhibits osteoclast differentiation
regulates bone resorption
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:glycosylation
|
present
|
|
gptkbp:HGNC_ID
|
11909
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNFRSF11B
|
|
gptkbp:inhibitedBy
|
RANKL-RANK interaction
|
|
gptkbp:interactsWith
|
TNFRSF11A (RANK)
TNFSF11 (RANKL)
|
|
gptkbp:length
|
401 amino acids (protein)
|
|
gptkbp:locatedOnChromosome
|
gptkb:8q24
|
|
gptkbp:location
|
extracellular space
secreted
|
|
gptkbp:memberOf
|
gptkb:tumor_necrosis_factor_receptor_superfamily
|
|
gptkbp:molecularWeight
|
46 kDa (protein)
|
|
gptkbp:mutationAssociatedWith
|
juvenile Paget's disease
|
|
gptkbp:OMIM
|
602643
|
|
gptkbp:orthologInMouse
|
Tnfrsf11b
|
|
gptkbp:proteinFamily
|
gptkb:TNF_receptor_superfamily
|
|
gptkbp:regulates
|
bone remodeling
bone mineral density
osteoclast activity
osteoblast-osteoclast signaling
|
|
gptkbp:signalPeptide
|
present
|
|
gptkbp:target
|
gptkb:denosumab
gptkb:teriparatide
romosozumab
|
|
gptkbp:UniProtID
|
O00300
|
|
gptkbp:bfsParent
|
gptkb:TNFRSF
|
|
gptkbp:bfsLayer
|
8
|