Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
gptkb:SMAD2
gptkb:SMAD3 TGF-β binding to receptor |
| gptkbp:can_be_dysregulated_in |
gptkb:disease
|
| gptkbp:conservedIn |
gptkb:metazoans
|
| gptkbp:formsComplexWith |
gptkb:SMAD4
|
| gptkbp:has_downstream_effectors |
transcription factors
|
| https://www.w3.org/2000/01/rdf-schema#label |
TGF-β signaling pathway
|
| gptkbp:inhibitedBy |
gptkb:SMAD7
|
| gptkbp:involves |
gptkb:SMAD_proteins
embryonic development wound healing cancer progression fibrosis TGF-β receptor TGF-β ligand |
| gptkbp:is_a_target_for |
therapeutic intervention
|
| gptkbp:modulatedBy |
gene expression
|
| gptkbp:namedAfter |
gptkb:transforming_growth_factor_beta
|
| gptkbp:regulates |
apoptosis
cell differentiation cell proliferation immune response extracellular matrix production |
| gptkbp:studiedBy |
molecular biology
|
| gptkbp:translocates |
SMAD complex to nucleus
|
| gptkbp:type |
signaling molecule
|
| gptkbp:bfsParent |
gptkb:KLF5
|
| gptkbp:bfsLayer |
8
|