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gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
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gptkbp:alternativeName
|
TRF2
Telomeric repeat binding factor 2
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gptkbp:associatedWith
|
gptkb:cancer
gptkb:dyskeratosis_congenita
|
|
gptkbp:component
|
shelterin complex
|
|
gptkbp:discoveredBy
|
Titia de Lange
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gptkbp:Entrez_Gene_ID
|
7014
ENSG00000108395
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gptkbp:expressedIn
|
gptkb:nucleus
|
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gptkbp:fullName
|
Telomeric repeat-binding factor 2
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gptkbp:function
|
binds telomeric DNA
protects telomeres
regulates telomere length
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gptkbp:geneType
|
protein-coding
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gptkbp:GO_term
|
gptkb:GO:0003691
GO:0005634
GO:0000723
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gptkbp:HGNC_ID
|
HGNC:11731
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TERF2
|
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gptkbp:inhibitedBy
|
ATM kinase activation at telomeres
non-homologous end joining at telomeres
|
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gptkbp:interactsWith
|
gptkb:RAP1
POT1
TPP1
TERF1
TIN2
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|
gptkbp:locatedOnChromosome
|
16
|
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gptkbp:location
|
16q22.1
|
|
gptkbp:molecularWeight
|
66 kDa
|
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gptkbp:mutationAssociatedWith
|
chromosomal instability
telomere dysfunction
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
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gptkbp:PDB
|
1H6P
|
|
gptkbp:phosphorylates
|
Ser323
Ser365
|
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gptkbp:regulates
|
telomere maintenance
DNA damage response at telomeres
chromosome end protection
telomere capping
|
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gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:sequence
|
available in GenBank
|
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gptkbp:UniProtID
|
Q15554
|
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gptkbp:bfsParent
|
gptkb:Microspherule_protein_1_(MCRS1)
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gptkbp:bfsLayer
|
8
|