T-cell

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf lymphocyte
gptkbp:abilities cancer cells
virus-infected cells
gptkbp:abnormalitiesCause leukemia
immunodeficiency
gptkbp:activatedBy antigen-presenting cell
gptkbp:developedBy hematopoietic stem cell
gptkbp:discoveredBy gptkb:Jacques_Miller
gptkbp:expressedIn gptkb:T-cell_receptor
gptkbp:firstDescribed 1960s
gptkbp:foundIn blood
lymphatic system
gptkbp:function cell-mediated immunity
https://www.w3.org/2000/01/rdf-schema#label T-cell
gptkbp:infects gptkb:HIV
gptkbp:involvedIn immunotherapy
autoimmune diseases
allergies
gptkbp:lifespan weeks to years
gptkbp:location lymph nodes
spleen
peripheral blood
mucosal tissues
gptkbp:marking gptkb:CD4
gptkb:CD8
gptkbp:maturation gptkb:thymus
gptkbp:percentageOfLymphocytes ~70%
gptkbp:produces cytokines
gptkbp:proliferatesIn response to antigen
gptkbp:recognizedBy MHC molecules
gptkbp:regulates other immune cells
gptkbp:relatedTo gptkb:B_cell
natural killer cell
gptkbp:requires immune response
gptkbp:response peptide antigens
gptkbp:role gptkb:adaptive_immune_system
tumor surveillance
transplant rejection
gptkbp:subspecies cytotoxic T cell
helper T cell
memory T cell
regulatory T cell
gptkbp:surfaceProtein gptkb:T-cell_receptor_(TCR)
gptkb:CD3
gptkb:CD4
gptkb:CD8
gptkbp:type white blood cell
gptkbp:usedIn gptkb:CAR-T_therapy
gptkbp:bfsParent gptkb:ALK-negative_anaplastic_large_cell_lymphoma
gptkb:ALK-positive_anaplastic_large_cell_lymphoma
gptkbp:bfsLayer 7