ALK-positive anaplastic large cell lymphoma

URI: https://gptkb.org/entity/ALK-positive_anaplastic_large_cell_lymphoma

GPTKB entity

Statements (51)

Predicate	Object
gptkbp:instanceOf	gptkb:disease leukemia
gptkbp:causedBy	gptkb:chromosomal_translocation_t(2;5)(p23;q35)
gptkbp:firstDescribed	1985
gptkbp:frequency	more common in males accounts for 10-15% of childhood non-Hodgkin lymphomas accounts for 2-3% of adult non-Hodgkin lymphomas
gptkbp:hasBiomarker	ALK gene rearrangement NPM-ALK fusion protein
gptkbp:hasGeneticAlteration	gptkb:A20-ALK_fusion gptkb:ATIC-ALK_fusion gptkb:CLTC-ALK_fusion gptkb:MSN-ALK_fusion gptkb:MYH9-ALK_fusion gptkb:NPM1-ALK_fusion gptkb:NPM1-ALK_fusion_protein gptkb:RNF213-ALK_fusion gptkb:TPM3-ALK_fusion gptkb:TPR-ALK_fusion gptkb:TRAF1-ALK_fusion
gptkbp:hasImmunophenotype	CD30 positive ALK positive CD3 negative or variable EMA positive
gptkbp:hasOrphanetID	ORPHA:98256
gptkbp:hasRelapseRisk	relapse possible after treatment
gptkbp:hasTypicalAgeOfOnset	children young adults
gptkbp:histology	horseshoe-shaped nuclei large anaplastic cells
https://www.w3.org/2000/01/rdf-schema#label	ALK-positive anaplastic large cell lymphoma
gptkbp:ICD-10_code	C84.6
gptkbp:originatedIn	gptkb:T-cell
gptkbp:prevalence	rare
gptkbp:prognosis	generally favorable in children and young adults worse prognosis in older adults
gptkbp:relatedTo	gptkb:ALK-negative_anaplastic_large_cell_lymphoma gptkb:primary_cutaneous_anaplastic_large_cell_lymphoma
gptkbp:stageName	gptkb:Ann_Arbor_staging_system
gptkbp:subspecies	gptkb:primary_cutaneous_ALK-positive_anaplastic_large_cell_lymphoma gptkb:systemic_ALK-positive_anaplastic_large_cell_lymphoma
gptkbp:symptom	fever weight loss lymphadenopathy night sweats
gptkbp:treatment	gptkb:brentuximab_vedotin chemotherapy stem cell transplant
gptkbp:WHOClassification	gptkb:mature_T-cell_and_NK-cell_neoplasm
gptkbp:bfsParent	gptkb:anaplastic_large_cell_lymphoma
gptkbp:bfsLayer	6