|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
SS2R
Somatostatin receptor 2
|
|
gptkbp:component
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
Yamada et al.
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodedBy
|
SSTR2 gene
|
|
gptkbp:Entrez_Gene_ID
|
6752
ENSG00000180616
|
|
gptkbp:expressedIn
|
brain
gastrointestinal tract
pancreas
|
|
gptkbp:fullName
|
Somatostatin receptor type 2
|
|
gptkbp:function
|
gptkb:G_protein-coupled_receptor
mediates effects of somatostatin
somatostatin receptor activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
G protein-coupled receptor signaling pathway
|
|
gptkbp:HGNC_ID
|
11330
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SSTR2
|
|
gptkbp:inhibitedBy
|
gptkb:adenylate_cyclase
hormone secretion
|
|
gptkbp:ligand
|
gptkb:somatostatin
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q24
chromosome 17q24
|
|
gptkbp:memberOf
|
somatostatin receptor family
|
|
gptkbp:molecularWeight
|
41 kDa
|
|
gptkbp:mutationAssociatedWith
|
acromegaly
neuroendocrine tumors
|
|
gptkbp:OMIM
|
182452
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Sstr2
|
|
gptkbp:PDB
|
gptkb:6ME6
|
|
gptkbp:RefSeq
|
NM_001050
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
neurotransmitter release
endocrine secretion
|
|
gptkbp:significance
|
target for neuroendocrine tumor imaging
target for somatostatin analog therapy
|
|
gptkbp:targetOfDrug
|
gptkb:octreotide
gptkb:lanreotide
gptkb:pasireotide
|
|
gptkbp:transmembraneDomains
|
7
|
|
gptkbp:UniProtID
|
P30874
|
|
gptkbp:bfsParent
|
gptkb:somatostatin
gptkb:PEN-221
gptkb:Somatostatin
|
|
gptkbp:bfsLayer
|
7
|