|
gptkbp:instanceOf
|
gptkb:protein
transcription factor
|
|
gptkbp:alias
|
gptkb:Specificity_protein_3
SP3
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
developmental disorders
|
|
gptkbp:binds
|
GC-rich motifs
|
|
gptkbp:domain
|
zinc finger domain
transactivation domain
|
|
gptkbp:encodedBy
|
gptkb:SP3_gene
|
|
gptkbp:Entrez_Gene_ID
|
6678
|
|
gptkbp:expressedIn
|
ubiquitous
|
|
gptkbp:family
|
gptkb:Sp/KLF_family
|
|
gptkbp:firstDescribed
|
1994
|
|
gptkbp:function
|
transcriptional activation
regulation of gene expression
DNA binding
transcriptional repression
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SP3 transcription factor
|
|
gptkbp:interactsWith
|
gptkb:SP1_transcription_factor
co-activators
co-repressors
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
2q31-q32
|
|
gptkbp:molecularWeight
|
~90 kDa
|
|
gptkbp:OMIM
|
601722
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
embryonic development
DNA repair
metabolism
cellular senescence
angiogenesis
inflammation
immune response
housekeeping genes
chromatin remodeling
cell cycle genes
apoptosis-related genes
|
|
gptkbp:UniProtID
|
Q02447
|
|
gptkbp:bfsParent
|
gptkb:SP2_transcription_factor
gptkb:SP3_gene
|
|
gptkbp:bfsLayer
|
8
|