|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Cu/Zn_superoxide_dismutase
gptkb:SOD1
|
|
gptkbp:associatedWith
|
gptkb:Amyotrophic_lateral_sclerosis
|
|
gptkbp:biologicalProcess
|
oxidative stress response
detoxification of reactive oxygen species
|
|
gptkbp:cofactor
|
copper
zinc
|
|
gptkbp:discoveredBy
|
gptkb:Irwin_Fridovich
|
|
gptkbp:discoveredIn
|
1969
|
|
gptkbp:encodedBy
|
gptkb:SOD1_gene
|
|
gptkbp:Entrez_Gene_ID
|
6647
|
|
gptkbp:enzymeCommissionNumber
|
EC 1.15.1.1
|
|
gptkbp:fullName
|
gptkb:Superoxide_dismutase_[Cu-Zn]
|
|
gptkbp:function
|
catalyzes the dismutation of superoxide radicals to oxygen and hydrogen peroxide
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SOD1 protein
|
|
gptkbp:length
|
153 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_21q22.11
|
|
gptkbp:location
|
gptkb:cytoplasm
mitochondria
|
|
gptkbp:molecularWeight
|
~16 kDa
|
|
gptkbp:mutationAssociatedWith
|
linked to familial ALS
|
|
gptkbp:OMIM
|
147450
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:1HL5
|
|
gptkbp:postTranslationalModification
|
disulfide bond formation
metal binding
|
|
gptkbp:presentIn
|
many eukaryotes
|
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gptkbp:proteinFamily
|
gptkb:superoxide_dismutase_family
|
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gptkbp:structure
|
homodimer
|
|
gptkbp:UniProtID
|
gptkb:P00441
|
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gptkbp:bfsParent
|
gptkb:rat_SOD1
|
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gptkbp:bfsLayer
|
6
|