Superoxide dismutase [Cu-Zn]

URI: https://gptkb.org/entity/Superoxide_dismutase_[Cu-Zn]
GPTKB entity
Statements (37)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:SOD1
CuZnSOD
superoxide:superoxide oxidoreductase
gptkbp:associatedWith amyotrophic lateral sclerosis
gptkbp:biologicalProcess antioxidant activity
superoxide dismutase activity
gptkbp:catalyzes dismutation of superoxide radicals
gptkbp:cofactor copper
zinc
gptkbp:discoveredBy gptkb:Irwin_Fridovich
gptkbp:discoveredIn 1969
gptkbp:EC_number 1.15.1.1
gptkbp:foundIn gptkb:cytoplasm
extracellular space
gptkbp:function protects cells from oxidative damage
gptkbp:gene gptkb:SOD1
gptkbp:gene_symbol_(bovine) gptkb:SOD1
gptkbp:heldBy metalloenzyme
https://www.w3.org/2000/01/rdf-schema#label Superoxide dismutase [Cu-Zn]
gptkbp:locatedOnChromosome gptkb:21q22.11
gptkbp:location cytosol
mitochondria (in some species)
gptkbp:molecularWeight ~16 kDa per subunit
gptkbp:mutationAssociatedWith linked to familial ALS
gptkbp:OMIM 147450
gptkbp:organism gptkb:Bos_taurus
gptkb:Homo_sapiens
gptkbp:PDB 1CBJ
gptkbp:product hydrogen peroxide
oxygen
gptkbp:proteinFamily gptkb:superoxide_dismutase_family
gptkbp:substrate gptkb:superoxide_anion
gptkbp:subunit homodimer
gptkbp:UniProtID gptkb:P00441
gptkbp:bfsParent gptkb:SOD1_protein
gptkbp:bfsLayer 7