|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:SARP-3
FRP-5
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:non-alcoholic_fatty_liver_disease
insulin resistance
|
|
gptkbp:discoveredBy
|
1998
|
|
gptkbp:domain
|
frizzled (Fz) domain
netrin domain
|
|
gptkbp:Entrez_Gene_ID
|
6425
ENSG00000104332
|
|
gptkbp:expressedIn
|
heart
retina
liver
adipose tissue
pancreas
|
|
gptkbp:family
|
secreted frizzled-related protein family
|
|
gptkbp:fullName
|
Secreted frizzled-related protein 5
|
|
gptkbp:function
|
modulates Wnt signaling pathway
inhibits Wnt proteins
|
|
gptkbp:gene
|
gptkb:SFRP5
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
GO:0016055 (Wnt signaling pathway)
GO:0005102 (receptor binding)
|
|
gptkbp:HGNC_ID
|
10777
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SFRP5
|
|
gptkbp:inhibitedBy
|
gptkb:Wnt5a
gptkb:Wnt3a
|
|
gptkbp:length
|
317 amino acids
|
|
gptkbp:locatedOnChromosome
|
10
|
|
gptkbp:location
|
10q24.1
|
|
gptkbp:molecularWeight
|
36 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Sfrp5
|
|
gptkbp:proteinFamily
|
secreted protein
|
|
gptkbp:regulates
|
gptkb:Wnt_signaling
|
|
gptkbp:relatedTo
|
gptkb:type_2_diabetes
cell proliferation
obesity
inflammation
adipogenesis
metabolic regulation
|
|
gptkbp:subcellularLocation
|
extracellular space
|
|
gptkbp:transcription_regulated_by
|
gptkb:Wnt_signaling
PPARĪ³
|
|
gptkbp:UniProtID
|
Q5T4F7
|
|
gptkbp:bfsParent
|
gptkb:TCF/LEF
|
|
gptkbp:bfsLayer
|
7
|