|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
FRP-2
SARP1
Secreted apoptosis-related protein 1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
fibrosis
|
|
gptkbp:chromosomeArm
|
4q31.3
|
|
gptkbp:discovered_year
|
1998
|
|
gptkbp:domain
|
Netrin domain
frizzled domain
|
|
gptkbp:Entrez_Gene_ID
|
6423
ENSG00000104332
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
heart
|
|
gptkbp:fullName
|
Secreted frizzled-related protein 2
|
|
gptkbp:function
|
modulates Wnt signaling pathway
acts as a Wnt antagonist
|
|
gptkbp:gene
|
gptkb:SFRP2
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
GO:0005576 (extracellular region)
GO:0016055 (Wnt signaling pathway)
GO:0005102 (signaling receptor binding)
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
10777
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SFRP2
|
|
gptkbp:length
|
295 amino acids
|
|
gptkbp:locatedOnChromosome
|
4
|
|
gptkbp:molecularWeight
|
35 kDa
|
|
gptkbp:OMIM
|
604462
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Sfrp2
|
|
gptkbp:pathway
|
gptkb:Wnt_signaling_pathway
|
|
gptkbp:PDB
|
2QVS
|
|
gptkbp:proteinFamily
|
frizzled-related proteins
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
angiogenesis
|
|
gptkbp:relatedTo
|
embryonic development
tissue regeneration
|
|
gptkbp:subcellularLocation
|
secreted
|
|
gptkbp:UniProtID
|
Q96HF1
|
|
gptkbp:bfsParent
|
gptkb:TCF/LEF
|
|
gptkbp:bfsLayer
|
7
|