|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:FRP
gptkb:SARP-2
gptkb:SDF-2
FRP1
SARP2
SDF2
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
glaucoma
|
|
gptkbp:biologicalProcess
|
Wnt-protein binding
receptor antagonist activity
|
|
gptkbp:cellularComponent
|
extracellular region
|
|
gptkbp:chromosomeArm
|
p
|
|
gptkbp:discovered_year
|
1997
|
|
gptkbp:Entrez_Gene_ID
|
6422
ENSG00000104332
|
|
gptkbp:expressedIn
|
downregulated in several cancers
widely expressed in adult tissues
|
|
gptkbp:fullName
|
Secreted frizzled-related protein 1
|
|
gptkbp:function
|
modulates Wnt signaling pathway
acts as a Wnt antagonist
|
|
gptkbp:gene
|
gptkb:SFRP1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
10777
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SFRP1
|
|
gptkbp:length
|
314
|
|
gptkbp:locatedOnChromosome
|
gptkb:8p11.21
8
chr8:41,222,964-41,246,964
|
|
gptkbp:molecularWeight
|
35 kDa
|
|
gptkbp:OMIM
|
601123
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Sfrp1
|
|
gptkbp:pathway
|
gptkb:Wnt_signaling_pathway
|
|
gptkbp:postTranslationalModification
|
glycosylation
disulfide bond formation
|
|
gptkbp:proteinFamily
|
NTR domain
frizzled (FZ) domain
frizzled-related proteins
|
|
gptkbp:regulates
|
epigenetically silenced in tumors
|
|
gptkbp:relatedTo
|
apoptosis
cell differentiation
cell proliferation
|
|
gptkbp:subcellularLocation
|
secreted
|
|
gptkbp:UniProtID
|
Q8N474
|
|
gptkbp:bfsParent
|
gptkb:TCF/LEF
|
|
gptkbp:bfsLayer
|
7
|