|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alsoKnownAs
|
gptkb:Drosha
|
|
gptkbp:associatedWith
|
microRNA biogenesis
|
|
gptkbp:biologicalProcess
|
endoribonuclease activity
|
|
gptkbp:cofactor
|
gptkb:DGCR8
|
|
gptkbp:component
|
gptkb:Microprocessor_complex
|
|
gptkbp:discoveredIn
|
2004
|
|
gptkbp:domain
|
double-stranded RNA-binding domain
Ribonuclease III domain
|
|
gptkbp:EC_number
|
3.1.26.3
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
cleaves primary microRNA (pri-miRNA)
initiates microRNA (miRNA) processing
|
|
gptkbp:gene
|
gptkb:DROSHA
|
|
gptkbp:GO_term
|
GO:0004519
|
|
gptkbp:inhibitedBy
|
phosphorylation
|
|
gptkbp:locatedIn
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
chromosome 5p13.3 (human)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:hereditary_hemorrhagic_telangiectasia
|
|
gptkbp:orthologIn
|
C. elegans drsh-1
Drosophila Pasha
|
|
gptkbp:product
|
pre-miRNA
|
|
gptkbp:regulates
|
gene expression
|
|
gptkbp:requires
|
embryonic development
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
pri-miRNA
|
|
gptkbp:UniProtID
|
gptkb:Q9NRR4
|
|
gptkbp:bfsParent
|
gptkb:Drosha_enzyme
|
|
gptkbp:bfsLayer
|
10
|
|
http://www.w3.org/2000/01/rdf-schema#label
|
Ribonuclease III Drosha
|