|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:contains
|
gptkb:RalA
gptkb:RalB
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:expressedIn
|
animal cells
human cells
|
|
gptkbp:function
|
molecular switch
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ral GTPases
|
|
gptkbp:interactsWith
|
gptkb:Exo84
gptkb:RalBP1
gptkb:Sec5
gptkb:exocyst_complex
|
|
gptkbp:involves
|
gptkb:cancer
gptkb:diabetes
neurological disorders
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_2_(RalB)
gptkb:chromosome_7_(RalA)
|
|
gptkbp:memberOf
|
gptkb:Ras_superfamily
|
|
gptkbp:orthologIn
|
gptkb:yeast
invertebrates
mammals
|
|
gptkbp:regulates
|
cell proliferation
prenylation
gene expression
vesicle trafficking
cell migration
phosphorylation
cytoskeletal dynamics
tumorigenesis
ubiquitination
post-translational modifications
|
|
gptkbp:relatedTo
|
gptkb:Ras_proteins
|
|
gptkbp:role
|
gptkb:synaptic_plasticity
apoptosis
cell survival
metastasis
immune response
neuronal development
autophagy
cell polarity
endocytosis
exocytosis
|
|
gptkbp:structure
|
G domain
|
|
gptkbp:target
|
therapeutic research
|
|
gptkbp:bfsParent
|
gptkb:RalGEF_pathway
|
|
gptkbp:bfsLayer
|
5
|