|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:RING1B
DING
E3 ubiquitin-protein ligase RING2
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
gene silencing
chromatin modification
protein binding
protein ubiquitination
zinc ion binding
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
chromatin
|
|
gptkbp:chromosomeArm
|
1q25.3
|
|
gptkbp:component
|
gptkb:Polycomb_Repressive_Complex_1
|
|
gptkbp:discoveredBy
|
1998
|
|
gptkbp:encodes
|
E3 ubiquitin-protein ligase RNF2
|
|
gptkbp:Entrez_Gene_ID
|
6045
ENSG00000143369
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
Ring Finger Protein 2
|
|
gptkbp:function
|
transcriptional repression
E3 ubiquitin ligase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
NM_002897
|
|
gptkbp:HGNC_ID
|
10070
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RNF2
|
|
gptkbp:interactsWith
|
gptkb:CBX_proteins
gptkb:RING1A
BMI1
UBC (UBE2D2)
|
|
gptkbp:length
|
336 amino acids
|
|
gptkbp:locatedOnChromosome
|
1
chr1:183,914,282-183,927,222
|
|
gptkbp:molecularWeight
|
39 kDa
|
|
gptkbp:OMIM
|
602850
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Rnf2
|
|
gptkbp:PDB
|
4R8P
6C8Y
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
stem cell maintenance
Hox gene expression
|
|
gptkbp:UniProtID
|
Q99496
|
|
gptkbp:bfsParent
|
gptkb:Ring_finger_proteins
gptkb:RING_finger_E3_ligases
gptkb:RING1B
|
|
gptkbp:bfsLayer
|
8
|