REV-ERBβ

GPTKB entity

Statements (45)
Predicate Object
gptkbp:instanceOf gptkb:protein
nuclear receptor
gptkbp:alternativeName NR1D2
Nuclear receptor subfamily 1 group D member 2
gptkbp:binds hemoglobin
gptkbp:biologicalProcess DNA binding
transcription factor activity
regulation of transcription, DNA-templated
circadian regulation of gene expression
gptkbp:cellularComponent gptkb:nucleus
gptkbp:encodedBy NR1D2 gene
gptkbp:Entrez_Gene_ID 9572
gptkbp:expressedIn gptkb:skeletal_muscle
brain
liver
adipose tissue
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:hasParalog gptkb:REV-ERBα
https://www.w3.org/2000/01/rdf-schema#label REV-ERBβ
gptkbp:interactsWith gptkb:HDAC3
co-repressor NCoR
gptkbp:ligand hemoglobin
gptkbp:locatedOnChromosome chromosome 3p24.1 (human)
gptkbp:memberOf nuclear receptor subfamily 1 group D
gptkbp:orthologIn gptkb:Mus_musculus
gptkbp:PDB 3N00
gptkbp:regulates lipid metabolism
glucose metabolism
cellular metabolism
autophagy
inflammatory response
mitochondrial biogenesis
sleep-wake cycle
clock genes
BMAL1 gene
circadian clock output genes
gptkbp:relatedTo circadian rhythm regulation
transcriptional repression
gptkbp:UniProtID Q14995
gptkbp:bfsParent gptkb:SR_90000
gptkb:SR_90001
gptkb:SR_90002
gptkb:SR_90003
gptkb:SR_90005
gptkbp:bfsLayer 8