Cullin-RING ubiquitin ligases
GPTKB entity
Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:E3_ubiquitin_ligase |
| gptkbp:alternativeName |
gptkb:CRL
|
| gptkbp:component |
Cullin protein
RING finger protein adaptor protein substrate receptor |
| gptkbp:contains |
gptkb:CUL4A
gptkb:RBX1 CUL1 CUL2 CUL3 CUL4B CUL5 RBX2 |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
ubiquitination
|
| gptkbp:inhibitedBy |
CAND1
|
| gptkbp:regulates |
signal transduction
transcription DNA replication cell cycle protein degradation |
| gptkbp:requires |
NEDD8 modification
|
| gptkbp:studiedIn |
cancer research
cell biology |
| gptkbp:subclassOf |
gptkb:ubiquitin_ligase
|
| gptkbp:target |
therapeutic drugs
|
| gptkbp:bfsParent |
gptkb:Raymond_J._Deshaies
|
| gptkbp:bfsLayer |
6
|
| https://www.w3.org/2000/01/rdf-schema#label |
Cullin-RING ubiquitin ligases
|