RBR E3 ubiquitin ligase family
GPTKB entity
Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:RBR_ligases
gptkb:RING-between-RING_E3_ligases |
| gptkbp:domain |
gptkb:IBR_domain
gptkb:RING1_domain gptkb:RING2_domain |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
ubiquitin ligase activity
|
| gptkbp:GO_term |
gptkb:GO:0061630
|
| gptkbp:hasMember |
gptkb:Parkin
gptkb:HHARI gptkb:HOIP gptkb:RNF144A |
| https://www.w3.org/2000/01/rdf-schema#label |
RBR E3 ubiquitin ligase family
|
| gptkbp:involvedIn |
ubiquitination
|
| gptkbp:mechanismOfAction |
forms thioester intermediate with ubiquitin
catalyzes transfer of ubiquitin from E2 to substrate |
| gptkbp:mutationAssociatedWith |
gptkb:Parkinson's_disease
|
| gptkbp:relatedTo |
protein degradation
autophagy cellular signaling |
| gptkbp:bfsParent |
gptkb:PARK2
|
| gptkbp:bfsLayer |
7
|