Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:biologicalProcess |
DNA repair
cell signaling protein degradation mitophagy |
| gptkbp:discoveredBy |
researchers in ubiquitin field
|
| gptkbp:domain |
gptkb:IBR_domain
gptkb:RING1_domain gptkb:RING2_domain |
| gptkbp:example |
gptkb:Parkin
gptkb:HHARI gptkb:HOIP gptkb:RNF144A RNF216 ARIH1 |
| gptkbp:firstDescribed |
early 2000s
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:fullName |
RING-between-RING E3 ubiquitin ligases
|
| gptkbp:function |
protein ubiquitination
E3 ubiquitin ligase activity |
| https://www.w3.org/2000/01/rdf-schema#label |
RBR ligases
|
| gptkbp:mechanismOfAction |
form thioester intermediate with ubiquitin
catalyze transfer of ubiquitin from E2 to substrate |
| gptkbp:mutationAssociatedWith |
gptkb:Parkinson's_disease
|
| gptkbp:relatedTo |
HECT-type E3 ligases
RING-type E3 ligases |
| gptkbp:bfsParent |
gptkb:RBR_E3_ubiquitin_ligase_family
|
| gptkbp:bfsLayer |
8
|