Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genetic disorder
|
| gptkbp:affects |
gptkb:RAS_gene
|
| gptkbp:amendedBy |
GTPase activity of RAS protein
|
| gptkbp:associatedWith |
gptkb:cancer
|
| gptkbp:canBe |
gptkb:KRAS_mutation
NRAS mutation HRAS mutation |
| gptkbp:cause |
constitutive activation of RAS protein
persistent signaling |
| gptkbp:commonIn |
gptkb:cancer
colorectal cancer pancreatic cancer |
| gptkbp:detects |
genetic testing
|
| gptkbp:firstDescribed |
1980s
|
| https://www.w3.org/2000/01/rdf-schema#label |
RAS mutation
|
| gptkbp:impact |
response to targeted therapy
|
| gptkbp:involves |
point mutation
|
| gptkbp:prevention |
GTP hydrolysis
|
| gptkbp:result |
uncontrolled cell proliferation
|
| gptkbp:target |
cancer drug development
|
| gptkbp:type |
oncogenic mutation
|
| gptkbp:bfsParent |
gptkb:Papillary_thyroid_cancer
|
| gptkbp:bfsLayer |
5
|