RAS gene family in humans

URI: https://gptkb.org/entity/RAS_gene_family_in_humans
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:containsGene gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
gptkbp:discoveredBy gptkb:Robert_Weinberg
gptkbp:encodes gptkb:Ras_protein
gptkbp:firstDescribed 1982
gptkbp:form GTP-bound
https://www.w3.org/2000/01/rdf-schema#label RAS gene family in humans
gptkbp:inactiveForm GDP-bound
gptkbp:involvedIn cell differentiation
cell proliferation
cell signaling
apoptosis regulation
gptkbp:locatedOnChromosome gptkb:chromosome_11_(HRAS)
gptkb:chromosome_12_(KRAS)
gptkb:chromosome_1_(NRAS)
gptkbp:memberOf oncogene family
gptkbp:mutationAssociatedWith gptkb:cancer
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Costello_syndrome
gptkb:Noonan_syndrome
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
gptkbp:product guanine nucleotide exchange factor
gptkbp:regulates gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
cell survival
cell cycle progression
gptkbp:target farnesyltransferase inhibitors
gptkbp:bfsParent gptkb:ras1_gene
gptkbp:bfsLayer 7