RAS gene family in humans

URI: https://gptkb.org/entity/RAS_gene_family_in_humans

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:containsGene	gptkb:HRAS gptkb:KRAS gptkb:NRAS
gptkbp:discoveredBy	gptkb:Robert_Weinberg
gptkbp:encodes	gptkb:Ras_protein
gptkbp:firstDescribed	1982
gptkbp:form	GTP-bound
gptkbp:inactiveForm	GDP-bound
gptkbp:involvedIn	cell differentiation cell proliferation cell signaling apoptosis regulation
gptkbp:locatedOnChromosome	gptkb:chromosome_11_(HRAS) gptkb:chromosome_12_(KRAS) gptkb:chromosome_1_(NRAS)
gptkbp:memberOf	oncogene family
gptkbp:mutationAssociatedWith	gptkb:cancer gptkb:Cardiofaciocutaneous_syndrome gptkb:Costello_syndrome gptkb:Noonan_syndrome
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Caenorhabditis_elegans gptkb:Drosophila_melanogaster
gptkbp:product	gptkb:guanine_nucleotide_exchange_factor
gptkbp:regulates	gptkb:MAPK/ERK_pathway gptkb:PI3K/AKT_pathway cell survival cell cycle progression
gptkbp:target	farnesyltransferase inhibitors
gptkbp:bfsParent	gptkb:ras1_gene
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	RAS gene family in humans