Progressive Supranuclear Palsy

GPTKB entity

Predicate	Object
gptkbp:instanceOf	neurodegenerative disease
gptkbp:abbreviation	gptkb:PSP
gptkbp:affects	gptkb:basal_ganglia brain frontal lobe midbrain
gptkbp:averageOnsetAge	60s
gptkbp:averageSurvivalAfterDiagnosis	5 to 10 years
gptkbp:causedBy	abnormal accumulation of tau protein
gptkbp:characterizedBy	stiffness speech difficulties difficulty with eye movements problems with balance slowed movement swallowing difficulties
gptkbp:diagnosedBy	clinical evaluation neurological examination MRI
gptkbp:differentialDiagnosis	gptkb:Parkinson's_disease gptkb:corticobasal_degeneration gptkb:multiple_system_atrophy
gptkbp:firstDescribed	gptkb:J.C._Richardson gptkb:Jerzy_Olszewski gptkb:John_Steele 1963
gptkbp:hasNoCure	true
https://www.w3.org/2000/01/rdf-schema#label	Progressive Supranuclear Palsy
gptkbp:ICD-10_code	G23.1
gptkbp:MeSH_ID	gptkb:D011379
gptkbp:OMIM	601104
gptkbp:parent	gptkb:tauopathy parkinsonism
gptkbp:prevalence	rare about 6 per 100,000 people
gptkbp:prognosis	progressive and fatal
gptkbp:riskFactor	age genetic factors (rare)
gptkbp:subspecies	gptkb:PSP-Richardson's_syndrome gptkb:PSP-parkinsonism gptkb:PSP-pure_akinesia
gptkbp:symptom	gptkb:depression bradykinesia rigidity sleep disturbances apathy cognitive impairment dysphagia frequent falls dysarthria vertical gaze palsy
gptkbp:treatment	occupational therapy physical therapy speech therapy medications for symptoms
gptkbp:bfsParent	gptkb:Atypical_Parkinsonian_Syndromes
gptkbp:bfsLayer	6