Poly(A)-binding protein, cytoplasmic 1

URI: https://gptkb.org/entity/Poly(A)-binding_protein,_cytoplasmic_1
GPTKB entity
Statements (42)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:PABPC1
PABP1
Polyadenylate-binding protein 1
gptkbp:associatedWith intellectual disability (rare mutations)
gptkbp:domain RNA recognition motif
gptkbp:Entrez_Gene_ID 26986
ENSG00000070756
gptkbp:expressedIn all tissues
gptkbp:function regulates translation initiation
binds to poly(A) tails of mRNA
regulates mRNA stability
gptkbp:gene gptkb:PABPC1
https://www.w3.org/2000/01/rdf-schema#label Poly(A)-binding protein, cytoplasmic 1
gptkbp:interactsWith gptkb:PAIP1
gptkb:PAIP2
gptkb:eIF4G
gptkbp:length 636
gptkbp:locatedOnChromosome 8q22.3
gptkbp:location gptkb:cytoplasm
stress granule
gptkbp:molecularWeight 70 kDa
gptkbp:OMIM 604212
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse Pabpc1
gptkbp:orthologInYeast Pab1
gptkbp:postTranslationalModification phosphorylation
methylation
gptkbp:RefSeq NM_002568.4
NP_002559.1
gptkbp:regulates mRNA decay
translation efficiency
mRNA deadenylation
gptkbp:requires embryonic development
gptkbp:structure C-terminal PABC domain
contains 4 RNA recognition motifs
gptkbp:subcellularLocation gptkb:P-bodies
gptkb:cytoplasm
gptkb:stress_granules
gptkbp:UniProtID P11940
gptkbp:bfsParent gptkb:PABE
gptkbp:bfsLayer 8