|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
PABP
PABP1
PABPC
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
cancer (dysregulation)
intellectual disability (rare)
|
|
gptkbp:component
|
gptkb:cytoplasm
|
|
gptkbp:domain
|
RNA recognition motif (RRM)
|
|
gptkbp:encodedBy
|
PABPC1 gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000007672
|
|
gptkbp:essentialGene
|
yes
|
|
gptkbp:expressedIn
|
ubiquitous
|
|
gptkbp:fullName
|
Poly(A) binding protein cytoplasmic 1
|
|
gptkbp:function
|
regulates translation
mRNA binding
binds to poly(A) tail of mRNA
regulates mRNA stability
|
|
gptkbp:gene
|
gptkb:PABPC1
|
|
gptkbp:GOProcess
|
regulation of translation
mRNA stabilization
|
|
gptkbp:HGNC_ID
|
HGNC:8554
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PABPC1
|
|
gptkbp:interactsWith
|
gptkb:PAIP1
gptkb:PAIP2
gptkb:CPEB1
EIF4G1
CNOT7
|
|
gptkbp:length
|
636 amino acids
|
|
gptkbp:locatedOnChromosome
|
8
8q22.3
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
approximately 70 kDa
|
|
gptkbp:numberOfExons
|
15
|
|
gptkbp:numberOfRRM
|
4
|
|
gptkbp:OMIM
|
604212
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Pabpc1
|
|
gptkbp:orthologInYeast
|
PAB1
|
|
gptkbp:PDB
|
2RRP
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
|
|
gptkbp:proteinFamily
|
Poly(A)-binding protein family
|
|
gptkbp:RefSeq
|
NM_002568
|
|
gptkbp:reviewedBy
|
gptkb:NCBI_Gene
gptkb:HGNC
gptkb:UniProt
gptkb:Ensembl
|
|
gptkbp:UniProtID
|
P11940
|
|
gptkbp:bfsParent
|
gptkb:PABE
gptkb:PABP_proteins
gptkb:poly(A)-binding_proteins
|
|
gptkbp:bfsLayer
|
8
|