Polo-like kinase

GPTKB entity

Statements (46)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abnormalActivityAssociatedWith gptkb:cancer
gptkbp:discoveredIn gptkb:Drosophila_melanogaster
gptkbp:domain Polo-box domain
Serine/threonine kinase domain
gptkbp:enzymeClassification EC 2.7.11.21
gptkbp:familyMember gptkb:PLK1
gptkb:PLK2
gptkb:PLK3
gptkb:PLK4
gptkb:PLK5
gptkbp:firstDescribed 1988
gptkbp:foundIn eukaryotes
gptkbp:function regulation of cell cycle
gptkbp:GO_term gptkb:GO:0004674
GO:0005634
GO:0005737
GO:0007067
GO:0005694
GO:0007059
GO:0000287
GO:0000086
GO:0005813
GO:0005815
https://www.w3.org/2000/01/rdf-schema#label Polo-like kinase
gptkbp:involvedIn mitosis
DNA damage response
cytokinesis
chromosome segregation
spindle assembly
centrosome maturation
gptkbp:namedAfter polo gene
gptkbp:orthologIn gptkb:PLK1
gptkb:PLK2
gptkb:PLK3
gptkb:PLK4
gptkb:PLK5
gptkbp:phosphorylates various mitotic substrates
gptkbp:regulates gptkb:Cyclin_B
Wee1
Aurora kinases
Cdc25C
gptkbp:target anticancer drugs
gptkbp:bfsParent gptkb:PLK
gptkb:Plk
gptkbp:bfsLayer 7