|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:abnormalActivityAssociatedWith
|
gptkb:cancer
|
|
gptkbp:discoveredIn
|
gptkb:Drosophila_melanogaster
|
|
gptkbp:domain
|
Polo-box domain
Serine/threonine kinase domain
|
|
gptkbp:enzymeClassification
|
EC 2.7.11.21
|
|
gptkbp:familyMember
|
gptkb:PLK1
gptkb:PLK2
gptkb:PLK3
gptkb:PLK4
gptkb:PLK5
|
|
gptkbp:firstDescribed
|
1988
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
regulation of cell cycle
|
|
gptkbp:GO_term
|
gptkb:GO:0004674
GO:0005634
GO:0005737
GO:0007067
GO:0005694
GO:0007059
GO:0000287
GO:0000086
GO:0005813
GO:0005815
|
|
gptkbp:involvedIn
|
mitosis
DNA damage response
cytokinesis
chromosome segregation
spindle assembly
centrosome maturation
|
|
gptkbp:namedAfter
|
polo gene
|
|
gptkbp:orthologIn
|
gptkb:PLK1
gptkb:PLK2
gptkb:PLK3
gptkb:PLK4
gptkb:PLK5
|
|
gptkbp:phosphorylates
|
various mitotic substrates
|
|
gptkbp:regulates
|
gptkb:Cyclin_B
Wee1
Aurora kinases
Cdc25C
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:bfsParent
|
gptkb:PLK
gptkb:Plk
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Polo-like kinase
|