Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:alias |
gptkb:Sak
Polo-like kinase 4 |
| gptkbp:associatedWith |
gptkb:cancer
microcephaly |
| gptkbp:discoveredBy |
Habedanck et al., 2005
|
| gptkbp:domain |
serine/threonine kinase domain
Polo-box domain |
| gptkbp:encodes |
Serine/threonine-protein kinase PLK4
|
| gptkbp:Entrez_Gene_ID |
10733
|
| gptkbp:enzymeClassification |
EC 2.7.11.21
|
| gptkbp:expressedIn |
various human tissues
|
| gptkbp:function |
cell cycle regulation
regulation of centriole duplication |
| gptkbp:HGNC_ID |
HGNC:28963
|
| https://www.w3.org/2000/01/rdf-schema#label |
PLK4
|
| gptkbp:inhibitedBy |
Centrinone
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_4
4q28.1 |
| gptkbp:memberOf |
Polo-like kinase family
|
| gptkbp:mutationAssociatedWith |
autosomal recessive microcephaly
|
| gptkbp:OMIM |
605031
|
| gptkbp:orthologInMouse |
Plk4
|
| gptkbp:phosphorylates |
CEP192
CEP152 STIL |
| gptkbp:regulates |
centrosome duplication
centriole biogenesis |
| gptkbp:UniProtID |
O00444
|
| gptkbp:bfsParent |
gptkb:PLK
gptkb:Plk |
| gptkbp:bfsLayer |
7
|