|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:tissue_plasminogen_activator
gptkb:urokinase
|
|
gptkbp:alternativeName
|
gptkb:PLG
angiostatin precursor
proplasmin
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
thrombosis
Plasminogen deficiency
|
|
gptkbp:cleavage
|
gptkb:staphylokinase
gptkb:streptokinase
|
|
gptkbp:component
|
extracellular region
|
|
gptkbp:discoveredBy
|
Charles H. F. Ricketts
|
|
gptkbp:encodedBy
|
gptkb:PLG_gene
|
|
gptkbp:enzymeCommissionNumber
|
EC 3.4.21.7 (for plasmin)
|
|
gptkbp:expressedIn
|
liver
|
|
gptkbp:foundIn
|
blood plasma
|
|
gptkbp:function
|
fibrinolysis
serine-type endopeptidase activity
|
|
gptkbp:GOProcess
|
fibrinolysis
|
|
gptkbp:halfLife
|
2.2 days
|
|
gptkbp:HGNC_ID
|
9071
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Plasminogen
|
|
gptkbp:inhibitedBy
|
gptkb:plasminogen_activator_inhibitor-1
alpha-2-antiplasmin
|
|
gptkbp:locatedOnChromosome
|
6q26-q27
|
|
gptkbp:medicalUse
|
treatment of ligneous conjunctivitis
|
|
gptkbp:molecularWeight
|
approximately 92 kDa
|
|
gptkbp:OMIM
|
173350
|
|
gptkbp:orthologIn
|
gptkb:Bos_taurus
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
4DUU
|
|
gptkbp:postTranslationalModification
|
cleavage
glycosylation
|
|
gptkbp:predecessor
|
plasmin
|
|
gptkbp:RefSeq
|
NM_000301
|
|
gptkbp:reviewedBy
|
gptkb:GeneReviews
gptkb:OMIM
gptkb:UniProt
|
|
gptkbp:significance
|
deficiency leads to impaired fibrinolysis
mutations cause Plasminogen deficiency type I and II
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
contains kringle domains
|
|
gptkbp:subcellularLocation
|
secreted
|
|
gptkbp:UniProtID
|
P00747
|
|
gptkbp:bfsParent
|
gptkb:PG4
|
|
gptkbp:bfsLayer
|
7
|